Stay up-to-date with the latest market trends one hour before the close of the markets on Wednesday. Explore the top gainers and losers during today's session in our detailed report.
Let's have a look at what is happening on the US markets in the middle of the day on Wednesday. Below you can find the top gainers and losers in today's session.
Calidi Biotherapeutics (NYSE American: CLDI), a clinical-stage biotechnology company developing targeted therapies to deliver genetic medicines, announced the pricing of an underwritten public offering for gross proceeds of $6 million before expenses. The offering includes about 1.47 million common stock units priced at $2.00 each and about 1.53 million pre-funded warrant units priced at $1.999 each, both paired with Series I warrants exercisable at $2.00 per share for five years. Ladenburg Thalmann is serving as sole book-running manager with Laidlaw & Company (U.K.) Ltd. as co-manager.
Intrigued by the market activity one hour before the close of the markets on Monday? Uncover the key winners and losers of today's session in our insightful analysis.
Curious to know what's happening on the US markets in the middle of the day on Monday? Join us as we explore the top gainers and losers in today's session.
Calidi Biotherapeutics (NYSE American: CLDI), a clinical-stage biotechnology company developing targeted therapies to deliver genetic medicines to metastatic disease sites, reported a Q2 2025 net loss of $5.7 million, or $1.99 per share, compared to a net loss of $7.4 million, or $16.75 per share, in Q2 2024. R&D expenses were $2.6 million versus $2.2 million last year, while G&A expenses were $3.1 million compared to $3.6 million. Calidi ended the quarter with $5.3 million in cash and $0.1 million in restricted cash. Recent highlights include new preclinical data on CLD-401 from the proprietary RedTail platform, showing enhanced efficacy through systemic delivery of an IL15 superagonist and immune-evasion via engineered CD55 expression; $4.6 million raised in a warrant inducement offering, bringing 2025 gross proceeds to $15.7 million; and FDA Fast Track Designation for CLD-201 in soft tissue sarcoma, with an open IND for a Phase 1 trial.
Researchers in China have discovered a way to supercharge the treatment of lung cancer by transplanting mitochondria into the tumor environment. This transplantation increases the effectiveness of chemotherapy while boosting the immune system’s ability to fight the cancer. The team combined cisplatin (a lung cancer chemo drug) with mitochondrial transplantation.
A recent genetic discovery has the potential to boost the effectiveness of cancer immunotherapy treatments . According to a study published in the journal Nature, the genetic discovery may improve cancer treatment outcomes in certain patients. Researchers stumbled upon the promising clue while they studied treatment outcomes in ovarian clear cell carcinoma (OCCC) patients post-immunotherapy.
ORLANDO, FL / ACCESS Newswire / August 1, 2025 / RedChip Companies will air interviews with Calidi Biotherapeutics, Inc. (NYSE American:CLDI) and Atossa Therapeutics, Inc. (Nasdaq:ATOS) on the RedChip Small Stocks, Big Money™ show, a sponsored program on Bloomberg TV this Saturday, August 2, at 7 p.m. Eastern Time (ET). Bloomberg TV is available in an estimated 73 million homes across the U.S.
Specificity Inc. (OTCID: SPTY), a next-generation digital marketing firm, has regained its status as a fully reporting SEC current filer—marking a key milestone as it continues to revolutionize audience targeting across digital platforms. Known for eliminating bots and irrelevant impressions, Specificity’s proprietary ad tech delivers precision-targeted ads across display, social, and Connected TV (CTV) to the same verified, high-intent audiences —maximizing ROI and minimizing waste.
For years, oncologists have been baffled by why checkpoint inhibitors work for some cancer patients and not others. This challenge has made it difficult for these immunotherapies to be widely used since it isn’t easy to predict who will benefit and yet the treatments are currently very expensive .
Calidi Biotherapeutics (NYSE American: CLDI), a clinical-stage biotechnology company developing targeted genetic medicine delivery therapies, announced that the U.S. Food and Drug Administration granted Fast Track designation to CLD-201 (SuperNova), its allogeneic adipose stem-cell loaded oncolytic virus for treating soft tissue sarcoma. The designation provides opportunities for expedited development, including priority review and accelerated approval. CLD-201, which received IND clearance in April, will enter a Phase 1 trial evaluating safety and efficacy in sarcoma, triple-negative breast cancer, and head and neck squamous cell carcinoma. Chief Medical Officer Guy Travis Clifton, M.D., said the milestone validates CLD-201’s potential to deliver durable, transformational treatment for patients with advanced tumors.
